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As a result of the discordance, the brain will come to the conclusion that the individual is hallucinating and further conclude that the hallucination is due to poison ingestion.The brain responds by inducing vomiting, to clear the supposed toxin.Nevertheless, the direct poison hypothesis argues that there still are plausible ways in which the body's poison response system may have played a role in shaping the evolution of some of the signature symptoms that characterize motion sickness.

The direct evolutionary hypothesis essentially argues that there are plausible means by which ancient real or apparent motion could have contributed directly to the evolution of aversive reactions, without the need for the co-opting of a poison response as posited by Treisman.

The area postrema in the brain is responsible for inducing vomiting when poisons are detected, and for resolving conflicts between vision and balance.

When feeling motion but not seeing it (for example, in a ship with no windows), the inner ear transmits to the brain that it senses motion, but the eyes tell the brain that everything is still.

Second is the operation of Sherrington's Law describing reciprocal inhibition between agonist-antagonist muscle pairs, and by implication the stretching of extraocular muscle that must occur whenever Sherrington's Law is made to fail, thereby causing an unrelaxed (contracted) muscle to be stretched.

Motion sickness, also known as kinetosis and travel sickness, is a condition in which a disagreement exists between visually perceived movement and the vestibular system's sense of movement.

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Depending on the cause, it can also be referred to as seasickness, car sickness, simulation sickness or airsickness.

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